Arid3b 56380

From TFCatWiki

(Redirected from MGI:1930768)
Jump to: navigation, search

External Links

Gene ID: 56380
Gene symbol: arid3b
Gene Description: at rich interactive domain 3b (bright like)
Aliases: Bdp; Dri2; MGC59291
Human Ortholog Gene ID: [10620]
Reviewer Judgement: TF Gene Candidate
Functional Classification: DNA-Binding: non-sequence-specific;

Transcription Factor Binding: tf co-factor binding

DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Arid Domain Family
Homolog Cluster(s): 13496

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10446990] DNA Binding; TF PPI Human Medium Coprecipitation experiments with in vitro translated human Bdp incubated with glutathione-agarose beads containing various truncated forms of GST-Rb fusion proteins showed that Bdp associates with the COOH-terminal region of pRb in vitro. EMSA experiments showed that in vitro translated human Bdp was able to bind DNA fragments in the MAR of the immunoglobulin heavy-chain gene that are located upstream of the S107 variable region promoter. Binding to either a mutated MAR oligonucleotide or a non-specific oligonucleotide was not tested, therefore specificity of DNA binding is unknown. Magdalena Swanson
Additional Reviewer Comments:
Reviewer: Magdalena Swanson

Arid3b is a TF gene candidate. GST-pull down experiments showed that in vitro translated human Bdp associates with GST-Rb fusion proteins. EMSA experiments showed that in vitro translated human Bdp was able to bind the MAR of the immunoglobulin heavy-chain gene. However, the specificity of binding to DNA sequences was not tested. More experiments are required for a definitive TF gene classification.


DISCUSSION PAGE link for this gene

VIEW gene annotation feedback in the [TFCat Annotation Feedback Reports Inquiry]

REPORT gene annotation feedback on the [TFCat Annotation Feedback Reporting System] Help is available here


The section below defines information for semantic searching. Please see the help page for more information on this section.

Facts about Arid3b 56380RDF feed
Gene description at rich interactive domain 3b (bright like)  +
Gene id 56,380  +
Gene judgment TF Gene Candidate  +
Gene symbol arid3b  +, Bdp  +, Dri2  +, and MGC59291  +
Gene taxonomy DNA-Binding: non-sequence-specific  +, and Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 13,496  +
Protein family 1.1 Helix-Turn-Helix Group/109 Arid Domain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
Personal tools