Myf5 17877

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Gene ID: 17877
Gene symbol: myf5
Gene Description: myogenic factor 5
Aliases: B130010J22Rik; Myf-5
Human Ortholog Gene ID: [4617]
Reviewer Judgement: TF Gene Candidate
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 11921


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[2385294] DNA Binding; Transactivation Mouse Medium old study shows activation domain by Gal4 fusion experiments; E12 interaction seems to be required for sequence specific binding. Jared Roach
[15497153] Transactivation Mouse Weak myf5 and myod overlap in function based on double knockout studies Jared Roach
Additional Reviewer Comments:
Reviewer: Jared Roach

Similar to MyoD, so is probably a TF. Cannot find direct published evidence for DNA binding. This reviewer comment is necessary at this stage in the annotation; if subsequent algorithms fail to identify this gene is a TF, we will need to modify the algorithms. Once this gene is identified by subsequent algorithms, this comment can be removed.

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Facts about Myf5 17877RDF feed
Gene description myogenic factor 5  +
Gene id 17,877  +
Gene judgment TF Gene Candidate  +
Gene symbol myf5  +, B130010J22Rik  +, and Myf-5  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 11,921  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
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