Myf6 17878

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Gene ID: 17878
Gene symbol: myf6
Gene Description: myogenic factor 6
Aliases: herculin; MRF4
Human Ortholog Gene ID: [4618]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 11921

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[1317551] Transactivation Mouse Medium Myf-6 can transactivate various muscle-specific promoters in gene reporter assays in NIH3T3 cells. Elodie Portales-Casamar
[2311584] DNA Binding Human Weak Myf-6 only very weakly interacts with a MEF or MLC enhancer oligonucleotides which are bound by Myf-3, Myf-4 and Myf-5 (EMSA). The residual affinity is not completely unspecific since AP1 and SBE binding sites do not form complexes. Elodie Portales-Casamar
[11076940] DNA Binding; Transactivation Human Strong myf6 binds to an element in the ACCbeta Promoter (yeast one-hybrid and EMSA experiments).

myf6 transactivates a gene reporter construct carrying 6 copies of this element in NIH3T3 cells.

Elodie Portales-Casamar
Additional Reviewer Comments:
Reviewer: Elodie Portales-Casamar

myf6 is a muscle specific TF, binding to specific sequences to transactivate the expression of muscle-specific genes.


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Facts about Myf6 17878RDF feed
Gene description myogenic factor 6  +
Gene id 17,878  +
Gene judgment TF Gene  +
Gene symbol myf6  +, herculin  +, and MRF4  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 11,921  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
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