Myod1 17927

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Gene ID: 17927
Gene symbol: myod1
Gene Description: myogenic differentiation 1
Aliases: AI503393; MYF3; MyoD; Myod-1
Human Ortholog Gene ID: [4654]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 11921


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12242286] DNA Binding Mouse Strong Gel mobility shift assays indicate murine MyoD binds specific sites in the myostatin gene upstream region. Experiments performed with expressed and purified MyoD, as well as C2C12 nuclear extracts. Results confirmed with ChIP assays in C2C12 cells. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Gel shift assays and ChIP assays indicate MyoD binds specific sites in the myostatin gene upstream region. Cotransfection experiments indicate MyoD preferentially up-regulates myostatin promoter activity.

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Facts about Myod1 17927RDF feed
Gene description myogenic differentiation 1  +
Gene id 17,927  +
Gene judgment TF Gene  +
Gene symbol myod1  +, AI503393  +, MYF3  +, MyoD  +, and Myod-1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 11,921  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
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