Myt1 17932

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Gene ID: 17932
Gene symbol: myt1
Gene Description: myelin transcription factor 1
Aliases: mKIAA0835; NZF-2a; NZF-2b; Nzf2; Nztf2
Human Ortholog Gene ID: [4661]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / BetaBetaAlpha-zinc finger Family
Homolog Cluster(s): 17932

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8980226] DNA Binding; Transactivation Human; Other Strong Selection/amplification experiments and DNase footprinting identify the DNA binding site Xenopus XMyT1 as AAAGTTT.

Transient tranfection MyT1 binding element promoter-reporter in HeLa cells (contain HMyT1) demonstrate that HMyT1 transactivates this promoter.

Debra Fulton
Additional Reviewer Comments:
Reviewer: Debra Fulton

Myt1 is a transcription factor. It binds DNA (by selection/amplification experiments and DNase footprinting) and transactivates an HMyT1 promoter-reporter gene.


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Facts about Myt1 17932RDF feed
Gene description myelin transcription factor 1  +
Gene id 17,932  +
Gene judgment TF Gene  +
Gene symbol myt1  +, mKIAA0835  +, NZF-2a  +, NZF-2b  +, Nzf2  +, and Nztf2  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 17,932  +
Protein family 2.1 Zinc-coordinating Group/17 BetaBetaAlpha-zinc finger Family  +
Protein group 2.1 Zinc-coordinating Group   +
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