Neurod4 11923

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Gene ID: 11923
Gene symbol: neurod4
Gene Description: neurogenic differentiation 4
Aliases: AI846749; ATH-3; Atoh3; MATH-3; Math3
Human Ortholog Gene ID: [58158]
Reviewer Judgement: TF Gene Candidate
Functional Classification:
Homolog Cluster(s): 11921


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12947105] Co-activation; Transactivation Mouse Medium On transient transfection assay with C3H10T1/2 cells, both Mash1 and Math3 weakly induced transcription from the E-box (CAGGTG)-containing promoter. This activation was significantly increased when the cofactor E47 was also co-expressed. Shannan HoSui
Additional Reviewer Comments:
Reviewer: Shannan HoSui

Math3, in combination with E47, enhanced activation of the luciferase reporter gene under the control of the E-box-containing promoter. While specific DNA-binding to the E-box has been shown for other members of the bHLH family of transcription factors, it has not been shown for Math3.

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Facts about Neurod4 11923RDF feed
Gene description neurogenic differentiation 4  +
Gene id 11,923  +
Gene judgment TF Gene Candidate  +
Gene symbol neurod4  +, AI846749  +, ATH-3  +, Atoh3  +, MATH-3  +, and Math3  +
Homolog cluster 11,921  +
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