Neurod6 11922

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Gene ID: 11922
Gene symbol: neurod6
Gene Description: neurogenic differentiation 6
Aliases: Atoh2; Math-2; Math2; MGC90713; Nex; Nex1m
Human Ortholog Gene ID: [63974]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 11921

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9308961] Other Mouse Weak NeuroD is not strictly specific to the neuronal lineage, however, and has been identified independently as a transcription factor of the insulin gene (B-2) in pancreatic cells Gwenael Breard
[9454850] Other Mouse Weak Spatio temporal expression of Nex in the CNS Gwenael Breard
[12562512] DNA Binding Mouse Strong By EMSA and site-directed mutagenesis, it has been demonstrated that Nex1 binds as homodimers and that the E1 E-box is a high affinity binding site. Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

By EMSA and site-directed mutagenesis, result shows that Nex1 binds as homodimers and that the E1 E-box is a high affinity binding site. NEX-1 is expressed abundantly in the mammalian central nervous system, but it is not strictly specific to the neuronal lineage, however, and has been identified independently as a transcription factor of the insulin gene (B-2) in pancreatic cells


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Facts about Neurod6 11922RDF feed
Gene description neurogenic differentiation 6  +
Gene id 11,922  +
Gene judgment TF Gene  +
Gene symbol neurod6  +, Atoh2  +, Math-2  +, Math2  +, MGC90713  +, Nex  +, and Nex1m  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 11,921  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
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