Neurog1 18014

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Gene ID: 18014
Gene symbol: neurog1
Gene Description: neurogenin 1
Aliases: AKA; Math4C; Neurod3; ngn1
Human Ortholog Gene ID: [4762]
Reviewer Judgement: TF Gene Candidate
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 11921

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10814830] Transactivation Mouse Medium Co-transfection of NDRF gene-driven luciferase reporter with an ngn1 expression vector into P19 cells, demonstrate ngn1 can transactivate the reporter construct. Mutations of E-boxes shows that transactivation of the NDRF gene by ngn1 is mediated through the E4 box. Alice Chou
Additional Reviewer Comments:
Reviewer: Alice Chou

Ngn1 transactivates a NDRF gene-driven luciferase reporter in P19 cells. Mutations of E-boxes shows that transactivation of the NDRF gene by ngn1 is mediated through the E4 box.


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Facts about Neurog1 18014RDF feed
Gene description neurogenin 1  +
Gene id 18,014  +
Gene judgment TF Gene Candidate  +
Gene symbol neurog1  +, AKA  +, Math4C  +, Neurod3  +, and ngn1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 11,921  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
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