Nkx3-2 12020

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Gene ID: 12020
Gene symbol: nkx3-2
Gene Description: nk3 homeobox 2
Aliases: Bapx1; Nkx-3.2; NKX3.2
Human Ortholog Gene ID: [579]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding;

DNA-Binding: sequence-specific

DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9256352] DNA Binding; Transactivation Human; Mouse Weak homologue of the Drosophila bagpipe homeobox gene i Wyeth Wasserman
[12746429] DNA Binding Mouse Strong Selex assay

Repressor activity suggested to be independent of DNA binding

Wyeth Wasserman
Additional Reviewer Comments:
Reviewer: Wyeth Wasserman

Sequence specific binding protein; homologue of fly bagpipe gene; some indication of repressor activity; regulated by Pax1 and Pax9 - as indicated by studies in pax1/pax9 null mice earliest developmental markers for the sclerotome portion of the somite and the gut mesentery. Bapx1 [?] continues to be expressed well into organogenesis in lateral plate mesoderm surrounding the mid- and hindgut, and in essentially all cartilaginous condensations which will subsequently undergo endochondral bone formation [from PMID 9256352]


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Facts about Nkx3-2 12020RDF feed
Gene description nk3 homeobox 2  +
Gene id 12,020  +
Gene judgment TF Gene  +
Gene symbol nkx3-2  +, Bapx1  +, Nkx-3.2  +, and NKX3.2  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +, and DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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