Nr1h5 381463

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Gene ID: 381463
Gene symbol: nr1h5
Gene Description: nuclear receptor subfamily 1, group h, member 5
Aliases: Fxrb; MGC141184
Human Ortholog Gene ID:
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12529392] DNA Binding; Transactivation Mouse Medium Nr1h5 (FXRbeta) showed lanosterol-induced transcriptional activity following transient transfection in HEK293 cells.

Nr1h5 binding site preferences were demonstrated by assessing it's transactivation potential using a panel of reporter plasmids containing consensus nuclear receptor binding sites.

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Nr1h5 (FXRbeta) showed lanosterol-induced transcriptional activity following transient transfection in HEK293 cells. Nr1h5 binding site preferences were demonstrated by assessing it's transactivation potential using a panel of reporter plasmids containing consensus nuclear receptor binding sites.


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Facts about Nr1h5 381463RDF feed
Gene description nuclear receptor subfamily 1, group h, member 5  +
Gene id 381,463  +
Gene judgment TF Gene  +
Gene symbol nr1h5  +, Fxrb  +, and MGC141184  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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