Nr1i2 18171

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Gene ID: 18171
Gene symbol: nr1i2
Gene Description: nuclear receptor subfamily 1, group i, member 2
Aliases: mPXR; PXR; PXR.1; PXR.2; PXR1; SXR
Human Ortholog Gene ID: [8856]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11114890] DNA Binding Human Strong The authors show by EMSA that SXR binds to the phenobarbital response element (PBRE). Luciferase reporter assays using a PBRE-luc construct show that SXR has transactivation functions as well. Reporter assays using the native CYP2B promoter show that SXR can transactivate CYP2B as well. Sarav Sundararajan
Additional Reviewer Comments:


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Facts about Nr1i2 18171RDF feed
Gene description nuclear receptor subfamily 1, group i, member 2  +
Gene id 18,171  +
Gene judgment TF Gene  +
Gene symbol nr1i2  +, mPXR  +, PXR  +, PXR.1  +, PXR.2  +, PXR1  +, and SXR  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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