Nr1i3 12355

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Gene ID: 12355
Gene symbol: nr1i3
Gene Description: nuclear receptor subfamily 1, group i, member 3
Aliases: AA209988; AI551208; CAR; CAR-beta; Care2; ESTM32; MB67; MGC107281
Human Ortholog Gene ID: [9970]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8114692] DNA Binding; Transactivation Human; Other Unknown Identified as a constitutive activator of a set of retinoic acid response elements. It binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes, both of which consist of a direct repeat hexamers related to the consensus AGGTCA, separated by 5 bp. Tim Hughes
[12511605] DNA Binding Human Strong DNA binding confirmed in at least one other gene by both Chip and EMSA. Tim Hughes
Additional Reviewer Comments:
Reviewer: Tim Hughes

Nr1i3 is a DNA-binding transcription factor. The encoded protein has the classical nuclear receptor domain structure including both a C4 zinc finger domain and a ligand binding domain. It was identified as a constitutive activator of a set of retinoic acid response elements. It binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes, both of which consist of a direct repeat hexamers related to the consensus AGGTCA, separated by 5 bp (PMID: 8114692). This has been confirmed in at least one other gene by both Chip and EMSA (PMID: 12511605).


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Facts about Nr1i3 12355RDF feed
Gene description nuclear receptor subfamily 1, group i, member 3  +
Gene id 12,355  +
Gene judgment TF Gene  +
Gene symbol nr1i3  +, AA209988  +, AI551208  +, CAR  +, CAR-beta  +, Care2  +, ESTM32  +, MB67  +, and MGC107281  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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