Nr2f6 13864

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Gene ID: 13864
Gene symbol: nr2f6
Gene Description: nuclear receptor subfamily 2, group f, member 6
Aliases: AV090102; COUP-TF3; EAR2; Erbal2
Human Ortholog Gene ID: [2063]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12690040] DNA Binding Mouse Strong Ear2 (Nr2f6) is identified as an interactor of the TGACCT (retinoic response element) motif in a yeast one-hybrid screen of 106 colonies from a mouse As4.1 cell cDNA library. Gel shift assays indicate Ear2 is able to bind to the site. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Yeast one-hybrid screens and get shift assays indicate Ear2 (Nr2f6) binds specifically to the retinoic response element. Cotransfection experiments show Nr2f6 functions as a transcriptional repressor of renin.


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Facts about Nr2f6 13864RDF feed
Gene description nuclear receptor subfamily 2, group f, member 6  +
Gene id 13,864  +
Gene judgment TF Gene  +
Gene symbol nr2f6  +, AV090102  +, COUP-TF3  +, EAR2  +, and Erbal2  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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