Nr3c1 14815

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Gene ID: 14815
Gene symbol: nr3c1
Gene Description: nuclear receptor subfamily 3, group c, member 1
Aliases: GR; Grl-1; Grl1
Human Ortholog Gene ID: [2908]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15563547] DNA Binding Human; Other; Mouse Strong One hundred and seven experimentally verified binding sites for 18 known NHRs were collected from the biomedical literature. Jaspar Database
[16728402] DNA Binding Human Strong Supershift assays in SK-N-BE(2)C cells indicates GR binds the MAOA promoter. Amy Ticoll
[67253380] DNA Binding Human Medium Purified GR DNA-binding domain binds the promoter region of CRH in DNase footprinting assays. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Supershift assays indicates GR binds the MAOA promoter. Transfection assays in SK-N-BE(2)C show GR modulates the transcription of MAOA.


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Facts about Nr3c1 14815RDF feed
Gene description nuclear receptor subfamily 3, group c, member 1  +
Gene id 14,815  +
Gene judgment TF Gene  +
Gene symbol nr3c1  +, GR  +, Grl-1  +, and Grl1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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