Nr3c2 110784

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Gene ID: 110784
Gene symbol: nr3c2
Gene Description: nuclear receptor subfamily 3, group c, member 2
Aliases: Mlr; MR
Human Ortholog Gene ID: [4306]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[3037703] Transactivation Human Strong NR3C2 was cloned by screening a human genomic DNA library with a probe derived from the human glucocorticoid receptor. A cloned DNA fragment, encoding part of the DNA binding domain, was used to screen a human kidney library to recover longer cDNA clones. The isolated NR3C2 clone could induce expression, in reponse to aldosterone treatment, of a reporter construct containing the MMTV-LTR in transiently transfected CV-1 cells. Rob Sladek
[8389140] DNA Binding Human Strong NR3C2, expressed in Sf21 insect cells, bound to probes containing a glucocorticoid reponse element (GRE) in gel shift assays. NR3C2 interaction with the GREs contained in the MMTV-LTR was confirmed by DNaseI footprinting. Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

NR3C2 was cloned by screening a human genomic DNA library with a probe derived from the human glucocorticoid receptor. A cloned DNA fragment, encoding part of the DNA binding domain, was used to screen a human kidney library to recover longer cDNA clones. NR3C2, expressed in Sf21 insect cells, bound to probes containing a glucocorticoid reponse element (GRE) in gel shift assays. NR3C2 induced expression, in reponse to aldosterone treatment, of a reporter construct containing the MMTV-LTR in transiently transfected CV-1 cells. NR3C2 interaction with the GREs contained in the MMTV-LTR was confirmed by DNaseI footprinting.


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Facts about Nr3c2 110784RDF feed
Gene description nuclear receptor subfamily 3, group c, member 2  +
Gene id 110,784  +
Gene judgment TF Gene  +
Gene symbol nr3c2  +, Mlr  +, and MR  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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