Nr4a1 15370

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Gene ID: 15370
Gene symbol: nr4a1
Gene Description: nuclear receptor subfamily 4, group a, member 1
Aliases: Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B; NGFIB; NP10; nur77; TIS1; TR3
Human Ortholog Gene ID: [3164]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[16237153] DNA Binding Mouse Strong In vitro produced NR4A1 binds to an NBRE in EMSA. NR4A1 binds an NBRE in the mouse and human INSL3 promoters in supershift assays using nuclear extracts from MA-10 Leydig cells. ChIP assays performed in MA-10 Leydig cells confirm NR4A1 is bound on the Insl3 promoter. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

NR4A1 binds to an NBRE in EMSAs. ChIP assays confirm NR4A1 is binds an NBRE on the Insl3 promoter. Transient transfection assays in MA-10 Leydig cells indicates NR4A1 activates a hINSL3 reporter construct.

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Facts about Nr4a1 15370RDF feed
Gene description nuclear receptor subfamily 4, group a, member 1  +
Gene id 15,370  +
Gene judgment TF Gene  +
Gene symbol nr4a1  +, Gfrp  +, GFRP1  +, Hbr-1  +, Hbr1  +, Hmr  +, N10  +, NGFI-B  +, NGFIB  +, NP10  +, nur77  +, TIS1  +, and TR3  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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