Nr5a1 26423

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Gene ID: 26423
Gene symbol: nr5a1
Gene Description: nuclear receptor subfamily 5, group a, member 1
Aliases: Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; MGC124277; MGC124278; SF-1; SF1
Human Ortholog Gene ID: [2516]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8463279] Other Mouse Not Selected Ad4BP Regulating Steroidogenic P-450 Gene Is a Member of Steroid

Hormone Receptor Superfamily

Gwenael Breard
[10913126] DNA Binding Mouse Strong This paper shown the different binding affinities of Nr5a1 PBox domain mutants for its DNA targets Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

Nr5a1 is an orphan nuclear receptor that binds DNA as a monomer and regulates the transcription of multiple target genes. Nr5a1 plays an essential role in the development of the adrenal gland, testis, ovary, pituitary gonadotropes, and hypothalamus. Nr5a1 regulates gene transcription through its interactions with nuclear receptor coactivators such as steroid receptor coactivator-1 and CREB-binding protein as well as by direct interactions with other transcription factors such as DAX-1, Egr-1, SOX9, WT-1, and CREB.


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Facts about Nr5a1 26423RDF feed
Gene description nuclear receptor subfamily 5, group a, member 1  +
Gene id 26,423  +
Gene judgment TF Gene  +
Gene symbol nr5a1  +, Ad4BP  +, ELP  +, ELP-3  +, Ftz-F1  +, Ftzf1  +, MGC124277  +, MGC124278  +, SF-1  +, and SF1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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