Nr6a1 14536

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Gene ID: 14536
Gene symbol: nr6a1
Gene Description: nuclear receptor subfamily 6, group a, member 1
Aliases: 1700113M01Rik; Gcnf; NCNF; RTR
Human Ortholog Gene ID: [2649]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9099702] DNA Binding; Transactivation Mouse Strong nr6a1 binds to specific oligonucleotides (SELEX and EMSA experiments).

nr6a1 is able to bind as a homodimer to its consensus binding site (EMSA). nr6a1can transactivate a gene reporter carrying 3 consensus binding site in its activated form only (in CV-1 cells).

Elodie Portales-Casamar
[15236322] DNA Binding; Transactivation Mouse Strong nr6a1 interacts with DR0 sequences in the protamine promoters (EMSA).

nr6a1 activates transcription through DR0s in GC-1 or JEG-3 cell lines (gene reporter assay). nr6a1 represses basal activity of the protamine promoters in a DR0-dependant manner in GC-1 or JEG-3 cell lines (gene reporter assay).

Elodie Portales-Casamar
Additional Reviewer Comments:
Reviewer: Elodie Portales-Casamar

nr6a1 binds to specific DNA sequences. It can bind as an homodimer and transactivate a reporter gene. It might have a repressor activity in some cases.


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Facts about Nr6a1 14536RDF feed
Gene description nuclear receptor subfamily 6, group a, member 1  +
Gene id 14,536  +
Gene judgment TF Gene  +
Gene symbol nr6a1  +, 1700113M01Rik  +, Gcnf  +, NCNF  +, and RTR  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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