Parp1 11545

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Gene ID: 11545
Gene symbol: parp1
Gene Description: poly (adp-ribose) polymerase family, member 1
Aliases: 5830444G22Rik; Adprp; Adprt1; AI893648; C80510; PARP; parp-1; PPOL; sPARP-1
Human Ortholog Gene ID: [142]
Reviewer Judgement: TF Gene Candidate
Functional Classification: Transcription Regulatory Activity: heterochromatin interaction/binding;

DNA-Binding: non-sequence-specific; Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific

DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / No Family Level Classification
Homolog Cluster(s): 11545

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10023680] DNA Binding Unknown Strong Bandshift and footprinting experiments show that PARP1 binds to the promoter of the quail Pax6 promoter in a sequence specific manner. Sarav Sundararajan
[10744766] Co-activation Human Strong Parp1 co-immunoprecipitates with b-MYB and enhances its transactivating activity in a luciferase reporter assay. Sarav Sundararajan
[12543974] Other Unknown Strong The authors show in drosophila that PARP1 is required in polytene chromosome puffs by fluorescent labelling of PARP1 with dsRed and is required for heat-shock induced puffing and hsp70 expression. Sarav Sundararajan
Additional Reviewer Comments:
Reviewer: Sarav Sundararajan

Some evidence of sequence-specific binding and transcriptional regulation, but most evidence indicates a role in transcriptional regulation through interactions with other transcription factors, or polyADP-Ribosylation of chromatin.


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Facts about Parp1 11545RDF feed
Gene description poly (adp-ribose) polymerase family, member 1  +
Gene id 11,545  +
Gene judgment TF Gene Candidate  +
Gene symbol parp1  +, 5830444G22Rik  +, Adprp  +, Adprt1  +, AI893648  +, C80510  +, PARP  +, parp-1  +, PPOL  +, and sPARP-1  +
Gene taxonomy Transcription Regulatory Activity: heterochromatin interaction/binding  +, DNA-Binding: non-sequence-specific  +, Transcription Factor Binding: tf co-factor binding  +, and DNA-Binding: sequence-specific  +
Homolog cluster 11,545  +
Protein family 2.1 Zinc-coordinating Group/999 No Family Level Classification  +
Protein group 2.1 Zinc-coordinating Group   +
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