Pgr 18667

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Gene ID: 18667
Gene symbol: pgr
Gene Description: progesterone receptor
Aliases: 9930019P03Rik; NR3C3; PR; PR-A; PR-B
Human Ortholog Gene ID: [5241]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[5579944] DNA Binding Other Medium Tissue specific binding in vitro of progesterone-receptor to the chromatins of chick tissues. Article one of the first on PGR (published 1971). Over 2000 articles with "progesterone receptor" in their title since then. Jared Roach
[12114521] Transactivation Human Weak "Although most studies of progesterone receptors (PR) and their two isoforms, PR-A and PR-B, focus on transcriptional stimulation, the receptors exhibit important inhibitory properties. Autoinhibition refers to an inhibitory function located in the PR N terminus, whose deletion increases transcriptional activity at least 6-10-fold. Transrepression refers to the ability of PR-A to suppress the transcriptional activity of PR-B and other nuclear receptors, including estrogen receptors. Self-squelching refers to the observation in transient transfection assays that increasing receptor concentrations paradoxically decrease transcriptional activity. Using a series of N-terminal deletion mutants constructed in both PR isoforms, we have mapped their autoinhibitory and transrepressor activities to a small ubiquitin-like modifier (SUMO-1) protein consensus-binding motif." Jared Roach
Additional Reviewer Comments:
Reviewer: Jared Roach

Well-known hormone receptor.


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Facts about Pgr 18667RDF feed
Gene description progesterone receptor  +
Gene id 18,667  +
Gene judgment TF Gene  +
Gene symbol pgr  +, 9930019P03Rik  +, NR3C3  +, PR  +, PR-A  +, and PR-B  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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