Phb2 12034

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Gene ID: 12034
Gene symbol: phb2
Gene Description: prohibitin 2
Aliases: AU044498; BAP; Bap37; Bcap37; REA
Human Ortholog Gene ID: [11331]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 12034

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10359819] TF PPI Human Strong REA is shown to interact with ER (estrogen receptor) in a yeast two-hybrid assay built from an MCF-7 breast cancer cell cDNA library. REA interacts directly with ER in in vitro GST "pull-down" assays. REA is not retained on the GST column without ER (or with GST alone). Amy Ticoll
[15173318] TF PPI Human Strong In a yeast two-hybrid screen, prohibitin 2 (PHB2) is found to specifically interact with Akt. PHB2 is specifically co-immunoprecipitated by regulatory factors Akt, MyoD and MEF2 but not by MKK6 or Six1 (negative controls) in Cos-7 cells co-transfected with PHB2. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

REA interacts directly with ER (estrogen receptor) in in vitro GST "pull-down" assays. REA is shown to interact with ER and Akt in yeast two-hybrid assays. PHB2 is specifically co-immunoprecipitated by Akt, MyoD and MEF2 but not by negative controls. PHB2 represses MyoD- or MEF2-dependent transcription in reporter assays of co-transfected C2C12 cells.


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Facts about Phb2 12034RDF feed
Gene description prohibitin 2  +
Gene id 12,034  +
Gene judgment TF Gene  +
Gene symbol phb2  +, AU044498  +, BAP  +, Bap37  +, Bcap37  +, and REA  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 12,034  +
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