Phox2a 11859

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Gene ID: 11859
Gene symbol: phox2a
Gene Description: paired-like homeobox 2a
Aliases: Arix; Phox2; Pmx2; Pmx2a
Human Ortholog Gene ID: [401]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11034547] DNA Binding; Transactivation Rat Strong Phox2b binds to homeodomain protein binding sites in the dopamine beta hydroxylase (DBH) promoter in gel shift assays. These studies used His-epitope-tagged Phox2b that was expressed in bacteria and affinity purified.

Phox2b activates a reporter construct controlled by the DBH promoter (bases -232 to +14) following transient transfection in HepG2 and NT2 cells. Cotransfection of constitutively active PKA markedly augmented Phox2b-mediated induction of DBH promoter activity.

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Phox2b binds to homeodomain protein binding sites in the dopamine beta hydroxylase (DBH) promoter in gel shift assays. Phox2b activates a reporter construct controlled by the DBH promoter (bases -232 to +14) following transient transfection in HepG2 and NT2 cells. Cotransfection of constitutively active PKA markedly augmented Phox2b-mediated induction of DBH promoter activity.


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Facts about Phox2a 11859RDF feed
Gene description paired-like homeobox 2a  +
Gene id 11,859  +
Gene judgment TF Gene  +
Gene symbol phox2a  +, Arix  +, Phox2  +, Pmx2  +, and Pmx2a  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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