Ppara 19013

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Gene ID: 19013
Gene symbol: ppara
Gene Description: peroxisome proliferator activated receptor alpha
Aliases: Nr1c1; Ppar; PPAR-alpha; PPARalpha
Human Ortholog Gene ID: [5465]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9748239] DNA Binding; Transactivation Human Strong The authors show that PPARa/RXRa heterodimers bind to the rat Apo-A1-A site through gel retardation assays. PPAR-alpha was also shown to activate the human, but not rat Apo-A1-A by CAT reporter assays. Sarav Sundararajan
[1537328] DNA Binding Rat Strong In this study the authors identified the peroxisome proliferator response element (PPRE) which contains a direct repeat of the sequence motifs TGACCT and TGTCCT and binds PPAR alpha. Gwenael Breard
[8123021] Other Mouse Unknown This paper relates the characterisation of the Mouse Ppara gene Gwenael Breard
[8386511] DNA Binding Rat Strong In this paper authors demonstrate that two members of the steroid hormone receptor family, termed the peroxisome proliferator activated receptor (PPAR alpha) and the retinoid X receptor (RXR alpha), co-operate to bind specifically to the peroxisome proliferator response element. Gwenael Breard
[12847522] Transactivation Mouse Strong Hypertension and diabetes are common side effects of glucocorticoid treatment. To determine whether PPAR-alpha mediates these sequelae, authors treated chronically with dexamethasone mice deficient in low-density lipoprotein receptor (Ldlr -/-), with (Ppara +/+) or without (Ppara -/-) PPAR-alpha. Ppara +/+, but not Ppara -/-, mice developed hyperglycemia, hyperinsulinemia, and hypertension. The Ppara +/+, but not Ppara -/-, mice developed hypertension. Adenoviral reconstitution of PPAR-alpha in the livers of nondiabetic, normotensive, dexamethasone-treated Ppara -/- mice induced hyperglycemia, hyperinsulinemia, and increased gluconeogenic gene expression. It also increased blood pressure, renin activity, sympathetic nervous activity, and renal sodium retention. Human hepatocytes treated with dexamethasone and a PPAR-alpha agonist showed induction of PPARA and gluconeogenic gene expression. These results identified hepatic activation of PPAR-alpha as a mechanism underlying glucocorticoid-induced insulin resistance Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

Ppara is a transcription factor that belongs to the nuclear hormone superfamily and controls the expression of genes involved in hepatic metabolism of glycerol.


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Facts about Ppara 19013RDF feed
Gene description peroxisome proliferator activated receptor alpha  +
Gene id 19,013  +
Gene judgment TF Gene  +
Gene symbol ppara  +, Nr1c1  +, Ppar  +, PPAR-alpha  +, and PPARalpha  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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