Ppara 19013

From TFCatWiki

Jump to: navigation, search

External Links

Gene ID: 19013
Gene symbol: ppara
Gene Description: peroxisome proliferator activated receptor alpha
Aliases: Nr1c1; Ppar; PPAR-alpha; PPARalpha
Human Ortholog Gene ID: [5465]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9748239] DNA Binding; Transactivation Human Strong The authors show that PPARa/RXRa heterodimers bind to the rat Apo-A1-A site through gel retardation assays. PPAR-alpha was also shown to activate the human, but not rat Apo-A1-A by CAT reporter assays. Sarav Sundararajan
[1537328] DNA Binding Rat Strong In this study the authors identified the peroxisome proliferator response element (PPRE) which contains a direct repeat of the sequence motifs TGACCT and TGTCCT and binds PPAR alpha. Gwenael Breard
[8123021] Other Mouse Unknown This paper relates the characterisation of the Mouse Ppara gene Gwenael Breard
[8386511] DNA Binding Rat Strong In this paper authors demonstrate that two members of the steroid hormone receptor family, termed the peroxisome proliferator activated receptor (PPAR alpha) and the retinoid X receptor (RXR alpha), co-operate to bind specifically to the peroxisome proliferator response element. Gwenael Breard
[12847522] Transactivation Mouse Strong Hypertension and diabetes are common side effects of glucocorticoid treatment. To determine whether PPAR-alpha mediates these sequelae, authors treated chronically with dexamethasone mice deficient in low-density lipoprotein receptor (Ldlr -/-), with (Ppara +/+) or without (Ppara -/-) PPAR-alpha. Ppara +/+, but not Ppara -/-, mice developed hyperglycemia, hyperinsulinemia, and hypertension. The Ppara +/+, but not Ppara -/-, mice developed hypertension. Adenoviral reconstitution of PPAR-alpha in the livers of nondiabetic, normotensive, dexamethasone-treated Ppara -/- mice induced hyperglycemia, hyperinsulinemia, and increased gluconeogenic gene expression. It also increased blood pressure, renin activity, sympathetic nervous activity, and renal sodium retention. Human hepatocytes treated with dexamethasone and a PPAR-alpha agonist showed induction of PPARA and gluconeogenic gene expression. These results identified hepatic activation of PPAR-alpha as a mechanism underlying glucocorticoid-induced insulin resistance Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

Ppara is a transcription factor that belongs to the nuclear hormone superfamily and controls the expression of genes involved in hepatic metabolism of glycerol.

DISCUSSION PAGE link for this gene

VIEW gene annotation feedback in the [TFCat Annotation Feedback Reports Inquiry]

REPORT gene annotation feedback on the [TFCat Annotation Feedback Reporting System] Help is available here

The section below defines information for semantic searching. Please see the help page for more information on this section.

Facts about Ppara 19013RDF feed
Gene description peroxisome proliferator activated receptor alpha  +
Gene id 19,013  +
Gene judgment TF Gene  +
Gene symbol ppara  +, Nr1c1  +, Ppar  +, PPAR-alpha  +, and PPARalpha  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
Personal tools