Rarg 19411

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Gene ID: 19411
Gene symbol: rarg
Gene Description: retinoic acid receptor, gamma
Aliases: AI385767; MGC11555; MGC18523; Nr1b3; RARD; RARgamma2
Human Ortholog Gene ID: [5916]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[2544807] DNA Binding; Transactivation Mouse Strong Rarg was cloned from a mouse 10.5d embryo library screeened with probes from the human RARA and RARB isoforms. The cloned protein activated a reporter construct containing three copies of a retinoic acid response element following transient transfection in HeLa cells. Rob Sladek
[15327771] DNA Binding; Transactivation Mouse Strong Rarg binds to a site in the murine RAR-beta2 gene promoter in chromatin immunoprecipitation assays performed using S91 melanoma cells.

Transient transfection studies show that Rarg activates a reporter containing 3 copies of a retinoic acid receptor response element in reponse to treatment with a synthetic retinoid in S91 melanoma cells.

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Rarg was cloned from a mouse 10.5d embryo library screeened with probes from the human RARA and RARB isoforms. Transient transfection studies show that the cloned protein activated a reporter construct containing three copies of a retinoic acid receptor response element (RARE) following retionic acid treatment in HeLa cells. Rarg binds to a site in the murine RAR-beta2 gene promoter in chromatin immunoprecipitation assays performed using S91 melanoma cells. Transient transfection studies show that Rarg activates a reporter containing 3 copies of a RARE in reponse to treatment with a synthetic retinoid in S91 melanoma cells.


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Facts about Rarg 19411RDF feed
Gene description retinoic acid receptor, gamma  +
Gene id 19,411  +
Gene judgment TF Gene  +
Gene symbol rarg  +, AI385767  +, MGC11555  +, MGC18523  +, Nr1b3  +, RARD  +, and RARgamma2  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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