Rfx1 19724

From TFCatWiki

Jump to: navigation, search

External Links

Gene ID: 19724
Gene symbol: rfx1
Gene Description: regulatory factor x, 1 (influences hla class ii expression)
Aliases: AI047719; AI385641
Human Ortholog Gene ID: [5989]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / RFX Domain Family
Homolog Cluster(s): 19724


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11986307] Co-activation; DNA Binding Human Medium EMSA shows RFX1 forms a homodimer and a heterodimer with RFX2 at collagen alpha 2(1) start site (-1 to +20) in human fibroblast. Amy Ticoll
[16464847] DNA Binding Human Strong DNA affinity pull-down assays were performed with IMR-90 nuclear extract indicate RFX1 binds the COL1A2 sequence. ChIP assays performed with HT1080 cells confirm the interaction. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

EMSA, DNA affinity pull-down, and ChIP assays show RFX1 binds the promoter region of collagen. RFX1 is found to repress collagen transcription in an in vitro transcription assay in human fibroblasts.

DISCUSSION PAGE link for this gene

VIEW gene annotation feedback in the [TFCat Annotation Feedback Reports Inquiry]

REPORT gene annotation feedback on the [TFCat Annotation Feedback Reporting System] Help is available here

The section below defines information for semantic searching. Please see the help page for more information on this section.

Facts about Rfx1 19724RDF feed
Gene description regulatory factor x, 1 (influences hla class ii expression)  +
Gene id 19,724  +
Gene judgment TF Gene  +
Gene symbol rfx1  +, AI047719  +, and AI385641  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 19,724  +
Protein family 1.2 Winged Helix-Turn-Helix/103 RFX Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
Personal tools