Rfx1 19724

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Gene ID: 19724
Gene symbol: rfx1
Gene Description: regulatory factor x, 1 (influences hla class ii expression)
Aliases: AI047719; AI385641
Human Ortholog Gene ID: [5989]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / RFX Domain Family
Homolog Cluster(s): 19724

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11986307] Co-activation; DNA Binding Human Medium EMSA shows RFX1 forms a homodimer and a heterodimer with RFX2 at collagen alpha 2(1) start site (-1 to +20) in human fibroblast. Amy Ticoll
[16464847] DNA Binding Human Strong DNA affinity pull-down assays were performed with IMR-90 nuclear extract indicate RFX1 binds the COL1A2 sequence. ChIP assays performed with HT1080 cells confirm the interaction. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

EMSA, DNA affinity pull-down, and ChIP assays show RFX1 binds the promoter region of collagen. RFX1 is found to repress collagen transcription in an in vitro transcription assay in human fibroblasts.


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Facts about Rfx1 19724RDF feed
Gene description regulatory factor x, 1 (influences hla class ii expression)  +
Gene id 19,724  +
Gene judgment TF Gene  +
Gene symbol rfx1  +, AI047719  +, and AI385641  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 19,724  +
Protein family 1.2 Winged Helix-Turn-Helix/103 RFX Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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