Runx1 12394

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Gene ID: 12394
Gene symbol: runx1
Gene Description: runt related transcription factor 1
Aliases: AI462102; AML1; Cbfa2; Pebp2a2; Pebpa2b
Human Ortholog Gene ID: [861]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Other
DBD Protein Group/Family Classification: Other / Runt Domain Family
Homolog Cluster(s): 12393

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[7609063] Transactivation Mouse Strong Transactivation experiments in mouse P19 cells demonstrate that a CBFa subunit encoded by the mouse Cbfa2 gene (Cbfa2-451) stimulates transcription from both the Mo-MLV and TCRb

chain enhancers (CAT assay).

Debra Fulton
[8035830] DNA Binding; Transactivation Mouse Strong Murine promoter (myeloperoxidase and netrophile elastase)-luciferase reporters are bound and activated by PEBP2/CBF (EMSA). Debra Fulton
Additional Reviewer Comments:
Reviewer: Debra Fulton

Transactivation with luciferase and CAT reporter assays demonstrate that PEBP2/CBF (AML1) is a transcription factor.


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Facts about Runx1 12394RDF feed
Gene description runt related transcription factor 1  +
Gene id 12,394  +
Gene judgment TF Gene  +
Gene symbol runx1  +, AI462102  +, AML1  +, Cbfa2  +, Pebp2a2  +, and Pebpa2b  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 12,393  +
Protein family 7 Other/110 Runt Domain Family  +
Protein group 7 Other   +
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