Runx1t1 12395

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Gene ID: 12395
Gene symbol: runx1t1
Gene Description: runt-related transcription factor 1; translocated to, 1 (cyclin d-related)
Aliases: Cbfa2t1h; ETO; MTG8
Human Ortholog Gene ID: [862]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 12395

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9724795] TF PPI Human Strong ETO is shown to bind the human homolog of the murine nuclear receptor corepressor (N-CoR) in a yeast two-hybrid system. Result is confirmed with GST coprecipitation assays. Immunoprecipitation in 293 cells indicates that ETO forms a complex with N-CoR, mSin3A, and HDAC1 in vivo. Amy Ticoll
[9819404] TF PPI Human Strong ETO interacts with the nuclear receptor corepressor N-CoR in yeast two-hybrid assay, GST-pulldown, and coimmunoprecipitation assays (Cos-7 cells). ETO is shown to associate with mSin3A and endogenous HDAC-2 proteins in coimmunoprecipitation assays. Endogenous ETO cosediments with mSin3A and N-CoR from HEL cell lysates. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

ETO is shown to interact with N-CoR in yeast two-hybrid, GST-pulldown, and coimmunoprecipitation assays. ETO cosediments with mSin3A and N-CoR. Immunoprecipitation indicates that ETO forms a complex with N-CoR, mSin3A, and HDAC1 in vivo. ETO together with these proteins represses transcription in transfection assays of CV-1 cells.


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Facts about Runx1t1 12395RDF feed
Gene description runt-related transcription factor 1; translocated to, 1 (cyclin d-related)  +
Gene id 12,395  +
Gene judgment TF Gene  +
Gene symbol runx1t1  +, Cbfa2t1h  +, ETO  +, and MTG8  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 12,395  +
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