Runx3 12399

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Gene ID: 12399
Gene symbol: runx3
Gene Description: runt related transcription factor 3
Aliases: AML2; Cbfa3; Pebp2a3
Human Ortholog Gene ID: [864]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Other
DBD Protein Group/Family Classification: Other / Runt Domain Family
Homolog Cluster(s): 12393

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15688019] Transactivation Human Medium RUNX3 promoter specific RNase protection assays (RPA) determine that that one RUNX3 isoform is being induced during B-cell stimulation (RT-PCR). RUNX3 proximal (isoform P2) promoter activity. Stable transfection of EBV-negative Akata 31 BL cells with inducible expression plasmids containing RUNX3 cDNA (P2 isoform) demonstrate that RUNX3 represses RUNX1 promoter-luciferase gene. Western blot of RUNX3 siRNAs knock down of RUNX1 expression demonstrates that RUNX3 represses transcription from the RUNX1 promoter. Debra Fulton
[16164020] DNA Binding; Transactivation Human Medium Transient transfection experiments in human cell line K562 (chronic myelogenous leukemia) reveal that RUNX3 transactivates the CD49d gene proximal promoter (luciferase-reporter gene). Debra Fulton
Additional Reviewer Comments:
Reviewer: Debra Fulton

RunX3 is a transcription factor. It induces transcription of CD49d promoter-luciferase gene and demonstrates a repressor activity on RUNX1 promoter-luciferase gene and its repressor effect is mitigated with the introduction of RUNX3 siRNAs.


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Facts about Runx3 12399RDF feed
Gene description runt related transcription factor 3  +
Gene id 12,399  +
Gene judgment TF Gene  +
Gene symbol runx3  +, AML2  +, Cbfa3  +, and Pebp2a3  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 12,393  +
Protein family 7 Other/110 Runt Domain Family  +
Protein group 7 Other   +
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