Sfpi1 20375

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Gene ID: 20375
Gene symbol: sfpi1
Gene Description: sffv proviral integration 1
Aliases: Dis-1; Dis1; PU.1; Sfpi-1; Spi-1; Tcfpu1; Tfpu.1
Human Ortholog Gene ID: [6688]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Ets Domain Family
Homolog Cluster(s): 104156

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9211934] DNA Binding; Transactivation Human Strong EMSA and DNAse1 footprint experiments show that PU.1 binds to the P47(phox) promoter. Luciferase reporter assays show that PU.1 can transactivate the P47(phox) promoter and that disruption of the PU.1 binding site abrogates this transactivation. Sarav Sundararajan
[10523830] DNA Binding Human Strong EMSA experiments show that Spi-1 binds to the Fli-1 and Ets-2 elements from the Fli-1 promoter. Sarav Sundararajan
[7624145] DNA Binding Human Strong DNA binding specificity is demonstrated in selection/amplification experiments. Jaspar Database
Additional Reviewer Comments:


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Facts about Sfpi1 20375RDF feed
Gene description sffv proviral integration 1  +
Gene id 20,375  +
Gene judgment TF Gene  +
Gene symbol sfpi1  +, Dis-1  +, Dis1  +, PU.1  +, Sfpi-1  +, Spi-1  +, Tcfpu1  +, and Tfpu.1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 104,156  +
Protein family 1.2 Winged Helix-Turn-Helix/16 Ets Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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