Smyd1 12180

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Gene ID: 12180
Gene symbol: smyd1
Gene Description: set and mynd domain containing 1
Aliases: 4632404M21Rik; Bop; C78565; Zmynd18
Human Ortholog Gene ID: [150572]
Reviewer Judgement: TF Gene Candidate
Functional Classification: Transcription Regulatory Activity: heterochromatin interaction/binding;

Transcription Factor Binding: tf co-factor binding

Homolog Cluster(s): 12180


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11923873] Transactivation; TF PPI Human; Mouse Strong A Bop-GAL4DBD fusion represses luciferase activity in a GAL4-luc reporter construct in-vitro. Bop co-immunoprecipitates with flag-tagged HDAC1, 2 and 3. Sarav Sundararajan
[12011100] TF PPI Mouse Strong Shows interaction by co-immunoprecipitation with flag-tagged skNAC. The authors also map the interaction regions on Bop through deletion constructs to the amino-terminal S region of the split S-ET domain, as well as the MYND domain. Sarav Sundararajan
Additional Reviewer Comments:
Reviewer: Sarav Sundararajan

No direct DNA binding evidence found, but regulates transcription through chromatin remodelling and/or interactions with skNAC (a transcriptional activator)

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Facts about Smyd1 12180RDF feed
Gene description set and mynd domain containing 1  +
Gene id 12,180  +
Gene judgment TF Gene Candidate  +
Gene symbol smyd1  +, 4632404M21Rik  +, Bop  +, C78565  +, and Zmynd18  +
Gene taxonomy Transcription Regulatory Activity: heterochromatin interaction/binding  +, and Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 12,180  +
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