Sp1 20683

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Gene ID: 20683
Gene symbol: sp1
Gene Description: trans-acting transcription factor 1
Aliases: 1110003E12Rik; AA450830; AI845540; Sp1-1
Human Ortholog Gene ID: [6667]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / BetaBetaAlpha-zinc finger Family
Homolog Cluster(s): 107586

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15282343] DNA Binding Mouse Strong DNA-binding Assay (DBA) involving complex capture on streptavidin-immobilized paramagnetic particles indicates Sp1 binds a specific site on the SMA enhancer. Results confirmed with EMSA. Cell extracts from mouse AKR-2B embryonic fibroblasts used. Amy Ticoll
[15589828] Transactivation Mouse Medium Transfection studies using various kidney cell lines reveal the Sp1 binding site of the Cldn19 promoter is crucial for transactivation. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

DNA-binding Assay (DBA) and EMSA indicates Sp1 binds the SMA enhancer. Transfection studies reveal the Sp1 binding site of the Cldn19 promoter is crucial for transactivation.


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Facts about Sp1 20683RDF feed
Gene description trans-acting transcription factor 1  +
Gene id 20,683  +
Gene judgment TF Gene  +
Gene symbol sp1  +, 1110003E12Rik  +, AA450830  +, AI845540  +, and Sp1-1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,586  +
Protein family 2.1 Zinc-coordinating Group/17 BetaBetaAlpha-zinc finger Family  +
Protein group 2.1 Zinc-coordinating Group   +
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