Tfdp1 21781

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Gene ID: 21781
Gene symbol: tfdp1
Gene Description: transcription factor dp 1
Aliases: Dp1; Drtf1
Human Ortholog Gene ID: [7027]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Transcription Factor Family
Homolog Cluster(s): 104394

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8446173] DNA Binding Human Strong The protein was isolated by virtue of its binding to a DNA sequence taken from the adenovirus E2A promoter. TFDP1 is a component of the DRTF1/E2F transcription factor complex, which coordinates events in the cell cycle by interacting with RB1, the retinoblastoma gene product, and RB-related proteins. Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

The E2F transcription factor family regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors. The protein was isolated by virtue of its binding to a DNA sequence taken from the adenovirus E2A promoter. TFDP1 is a component of the DRTF1/E2F transcription factor complex, which coordinates events in the cell cycle by interacting with RB1, the retinoblastoma gene product, and RB-related proteins TFDP1 has a predicted sequence of 410 amino acids with a region of similarity to E2F1, accounting for the ability of both to bind the same DNA sequence.


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Facts about Tfdp1 21781RDF feed
Gene description transcription factor dp 1  +
Gene id 21,781  +
Gene judgment TF Gene  +
Gene symbol tfdp1  +, Dp1  +, and Drtf1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 104,394  +
Protein family 1.2 Winged Helix-Turn-Helix/15 Transcription Factor Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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