Vdr 22337

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Gene ID: 22337
Gene symbol: vdr
Gene Description: vitamin d receptor
Aliases: Nr1i1
Human Ortholog Gene ID: [7421]
Reviewer Judgement: TF Gene; TF Gene Candidate
Functional Classification: Transcription Factor Binding: tf co-factor binding;

DNA-Binding: sequence-specific

DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8674817] DNA Binding Human Strong DNA binding specificity is demonstrated in selection/amplification experiments. Jaspar Database
[16750418] Co-activation; DNA Binding Human Strong DNase I footprinting analysis indicates regions with putative VDREs within the 5-LO promoter. EMSA studies show VDR/RXR binds to these sites. Results confirmed with ChIP assays in MM6 cells. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

DNase footprinting, EMSA, and ChIP studies indicate specific VDR/RXR binding regions on the 5-LO promoter. Prominent induction in transfection assays is not achieved.

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Facts about Vdr 22337RDF feed
Gene description vitamin d receptor  +
Gene id 22,337  +
Gene judgment TF Gene  +, and TF Gene Candidate  +
Gene symbol vdr  +, and Nr1i1  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +, and DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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