Ctnnb1 12387

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Gene ID: 12387
Gene symbol: ctnnb1
Gene Description: catenin (cadherin associated protein), beta 1
Aliases: Catnb; Mesc
Human Ortholog Gene ID: [1499]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 12387


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9671490] Co-activation Mouse Strong Fusion proteins containing the amino- or carboxyl-terminal region of Beta-catenin stimulated transcription of a GAL-CAT reporter gene in transfected Neuro2A cells. Transient transfection of mouse neuroblastoma (Neuro2A) with LEF-CAT reporter demonstrate transcriptional activation by Beta-catenin-LEF-1 fusion proteins. The specificity of DNA binding by these complexes was confirmed by competition experiments. Debra Fulton
[11983900] Co-activation; Transactivation Mouse Medium Movo1 promoter-luciferase gene is activated by both Lef-1 and Beta-catenin together. Debra Fulton
Additional Reviewer Comments:
Reviewer: Debra Fulton

CAT reporter and lucferase reporter assays demonstrate that Beta-catenin is required by LEF-1 to activate transcription.

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Facts about Ctnnb1 12387RDF feed
Gene description catenin (cadherin associated protein), beta 1  +
Gene id 12,387  +
Gene judgment TF Gene  +
Gene symbol ctnnb1  +, Catnb  +, and Mesc  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 12,387  +
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