Human RARB

retinoic acid receptor, beta

By David Laperriere, Marieke Rozendaal, and Sylvie Mader

Classification	Homo sapiens » Zinc-coordinating Group » Hormone-nuclear Receptor Family » Subfamily 1 (TR, RAR, PPAR, REV-ERB, E78, RZR/ROR, CNR14, ECR, VDR, DHR96, NHR1, and 27 individual genes)
Related TF(s)	(none defined here)
Homologs	• Rarb
Links	ENSG00000077092 (Ensembl) 5915 (Entrez Gene) Homologene 180220 (OMIM)
Synonyms	RRB2, NR1B2, HAP

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Overview

Aberration in the level of RARB in premalignant and malignant tissues is associated with tumorigenesis ^[1]^[2]. The expression of RARB is reduced or lost in many types of cancer. Altered RARB expression has been observed in the cancer of the head and neck, breast, lung, oesophagus, pancreas, cervix and prostate ^[3]. Pharmacological doses of retinoic acid, alone or in combination with DNA demethylating and histone acetylating agents, restore in some cases the expression of RARB and inhibit the growth of tumor cells ^[1]^[4].

References

Sun SY et al. Evidence that retinoic acid receptor beta induction by retinoids is important for tumor cell growth inhibition. J. Biol. Chem., 275(22):17149-53. (PMID 10747926)
Xu XC. Tumor-suppressive activity of retinoic acid receptor-beta in cancer. Cancer Lett., 253(1):14-24. (PMID 17188427)

Sun SY and Lotan R. Retinoids and their receptors in cancer development and chemoprevention. Crit. Rev. Oncol. Hematol., 41(1):41-55. (PMID 11796231)
Soprano DR et al. Retinoic acid receptors and cancers. Annu. Rev. Nutr., 24:201-21. (PMID 15189119)

Expression (automatically populated)

About this section

The expression data displayed in this section is sourced from the UCSC Genome Browser. Karolchik D, Kuhn RM, Baertsch R, Barber GP, Clawson H, Diekhans M, Giardine B, Harte RA, Hinrichs AS, Hsu F, Kober KM, Miller W, Pedersen JS, Pohl A, Raney BJ, Rhead B, Rosenbloom KR, Smith KE, Stanke M, Thakkapallayil A, Trumbower H, Wang T, Zweig AS, Haussler D, Kent WJ. The UCSC Genome Browser Database: 2008 update. Nucleic Acids Res. 2008 Jan;36(Database issue):D773-9. Epub 2007 Dec 17.

GNF Expression Atlas 2 Data from U133A and GNF1H Chips
Using GNF ID 205080_at that is linked to Ensembl Transcript ID ENST00000330688

1. Fetal brain	17
2. Whole brain	0

3. Temporal lobe	14
4. Parietal lobe	-38
5. Occipital lobe	-23
6. Prefrontal cortex	24
7. Cingulate cortex	15
8. Cerebellum	-4
9. Cerebellum peduncles	-38
10. Amygdala	-24
11. Hypothalamus	-11
12. Thalamus	-29
13. Subthalamic nucleus	-3
14. Caudate nucleus	29
15. Globus pallidus	-18
16. Olfactory bulb	-3
17. Pons	14
18. Medulla oblongata	8

19. Spinal cord	0
20. Ciliary ganglion	3
21. Trigeminal ganglion	-2
22. Superior cervical ganglion	8
23. Dorsal root ganglion	21

24. Thymus	-15
25. Tonsil	-7
26. Lymph node	3
27. Bone marrow	22

28. BM-CD71+ early erythroid	17
29. BM-CD33+ myeloid	-20
30. BM-CD105+ endothelial	-44
31. BM-CD34+	-31
32. Whole blood	-23

33. PB-BDCA4+ dentritic cells	-31
34. PB-CD14+ monocytes	-100
35. PB-CD56+ NKCells	-50
36. PB-CD4+ Tcells	-41
37. PB-CD8+ Tcells	-16
38. PB-CD19+ Bcells	-19

39. Leukemia lymphoblastic (molt4)	-22
40. 721 B lymphoblasts	-38
41. Lymphoma Burkitts Raji	36
42. Leukemia promyelocytic (hl60)	-31
43. Lymphoma Burkitts Daudi	11
44. Leukemia chronic myelogenous (k562)	-13
45. Colorectal adenocarcinoma	-16

46. Appendix	25
47. Skin	-4
48. Adipocyte	-7
49. Fetal thyroid	3
50. Thyroid	8
51. Pituitary gland	21

52. Adrenal gland	14
53. Adrenal cortex	13

54. Prostate	-6
55. Salivary gland	20
56. Pancreas	-4
57. Pancreatic islets	15

58. Atrioventricular node	-6
59. Heart	2
60. Cardiac myocytes	38
61. Skeletal muscle	-28
62. Tongue	-12
63. Smooth muscle	51
64. Uterus	11
65. Uterus corpus	26
66. Trachea	7

67. Bronchial epithelial cells	6
68. Fetal lung	-4
69. Lung	-8

70. Kidney	13
71. Fetal liver	-26
72. Liver	15
73. Placenta	1

74. Testis	-63
75. Testis Leydig cell	0
76. Testis germ cell	-20
77. Testis interstitial	-22
78. Testis seminiferous tubule	-24
79. Ovary	-2

Mouse Brain Expression Data from Allen Brain Atlas

Link to MGI (MGI:97857) Link to Allen Brain Atlas (Rarb)

Retinoic acid receptor, beta (Mouse)

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